ANTICANCER POTENTIAL OF Elephantopus scaber L. LEAVES AGAINST MCF -7 CELL LINES
R. JASMINE *
Department of Biotechnology, Bishop Heber College, Trichy, India.
N. ABARNA
Department of Biotechnology, Bishop Heber College, Trichy, India.
STEPHY VERGHESE
Department of Zoology, Bishop Heber College, Trichy, India.
*Author to whom correspondence should be addressed.
Abstract
This study aimed to evaluate the cytotoxicity of Elephantopus scaber leaves against breast cancer cell lines. Leaves of the plant were collected, washed, shade dried and powdered. The ethanol extract of the leaf powder was used for the study. The anticancer activity of the ethanol extract of the leaves was evaluated using MTT assay against MCF-7 cells and was confirmed by ETBR-AO staining. The study confirms that the leaf extract of E.scaber has pronounced anticancer potential against MCF-7 cell lines. The plant investigated possesses remarkable anticancer activity, where the effect was dose dependent and the IC50 value was found to be 79.56 μg /ml. Since the preliminary data is promising, isolation of the compound may contribute to the development at a novel and natural phytomedicine for the disease. Additional studies are needed to determine its mode of action.
Keywords: Elephantopus scaber, MTT assay, anti-cancer, MCF-7, ETBR-AO stain, ethanol extract