IDENTIFICATION OF ANTIULCER ACTIVITY BY INSILICO METHOD IN SELECTED MEDICINAL PLANTS
R. SHARMILA *
Biotechnology Department, Bishop Heber College, Bharathidasan University, Trichirappalli, Tamilnadu, India.
S. P. RAJA RAJESHWARI
Biotechnology Department, Bishop Heber College, Bharathidasan University, Trichirappalli, Tamilnadu, India.
T. I. REVATHY
Biotechnology Department, Bishop Heber College, Bharathidasan University, Trichirappalli, Tamilnadu, India.
R. SARONA
Biotechnology Department, Bishop Heber College, Bharathidasan University, Trichirappalli, Tamilnadu, India.
M. SAPPANA SHREE
Biotechnology Department, Bishop Heber College, Bharathidasan University, Trichirappalli, Tamilnadu, India.
A. PREETHI
Biotechnology Department, Bishop Heber College, Bharathidasan University, Trichirappalli, Tamilnadu, India.
N. PRASANTH
Biotechnology Department, Bishop Heber College, Bharathidasan University, Trichirappalli, Tamilnadu, India.
K. AKILA
Biotechnology Department, Bishop Heber College, India.
*Author to whom correspondence should be addressed.
Abstract
Ulcer occurs when stomach acid damages the lining of the digestive tract caused by the bacteria Helicobacter pylori. Many pharmacological activities such as antiulcer activity can act against ulcer. Medicinal plants like Mimosa pudica and Vachellia nilotica has the antiulcer activity in a wide range. To study the antiulcer activity in medicinal plants using insilco studies by comparing the phytocompounds of plants with histamine 2 receptor as a binding protein, which is present in the stomach lining of homosapiens. Histamine 2 receptor was modelled using Swiss model and the ligand structures are obtained from PUB-CHEM, viewed easily via PYMOL. All the phytocompounds showed good binding energy with modelled protein on the docking methodology. Specifically ascorbic acid exhibited the lower binding energy of value -3.24 kcal/mol, indole and catechin shows highest binding energy of value -4.99 kcal/mol and -4.98 kacl/mol respectively. The results can be useful for the design and development of phytocompounds having better inhibitory activity against several types of ulcer.
Keywords: Histamine 2 receptor, homology modeling, docking, mimosins, binding interactions