PHARMACOLOGICAL AND ANTI CANCER ACTIVITY OF Ipomoea sepiaria METHANOLIC EXTRACT AGAINST PC-3 CELL LINE

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Published: 2020-12-26

Page: 88-94


S. AZHAGU MADHAVAN *

Deparment of Zoology & Biotechnology, A Veeriya Vandayar Memorial Sri Pushpam College, (Autonomous) Poondi, Thanjavur, 613503, Tamil Nadu, India.

P. VINOTHA

Department of Bio-Chemistry, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.

V. UMA

Department of Bio-Chemistry, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.

*Author to whom correspondence should be addressed.


Abstract

A few conventional restorative plants contain in explored concerning their enemy of corpulence likely wellsprings of is Ipomoea sepiaria Koenig ex. Roxb. The medicine is supposed in tales game plan of prescription for various accommodating properties like, love elixir and arsenic hurting, tonic, re-establishing, diuretic, laxative, uterotonic and sterility in women and leaves is shown particularly in diabetes. Phytochemical screening of different concentrates of Ipomoea sepiaria exposed the presence and non-attendance of various phytochemicals are available in ethanol remove, further examinations were done with leaves of Ipomoea sepiaria ethanol separate. PC3 (PC-3) is a human prostate malignancy cell lines that are profoundly utilized in examining the biochemical changes prostatic disease cells. Explores on PC-3 human prostate malignancy cell lines control are required in the current many years. The anticancer action of fluid concentrate of Ipomoea sepiaria was researched by 3-(4,5-dimethylthiazol-2-yl)- 2, 5-diphenyltetrazolium (MTT) measure utilizing PC-3 cell line. The current experimentation was indicated that watery concentrate of Ipomoea sepiaria, when exposed to various focuses on PC-3 cells demonstrated IC50 cell hindrance at about 5μM for 48 hours and about 2 μM for 72 hours. The information made by this particular examination gives relevant pharmacognostic  and phytochemical data needed for proper distinctive confirmation and check of leaves of this particular  species.

 

Keywords: Fluorescence, Ipomoea sepiaria, inorganic elements, phytochemicals, PC-3 human prostate cancer cell lines.


How to Cite

MADHAVAN, S. AZHAGU, P. VINOTHA, and V. UMA. 2020. “PHARMACOLOGICAL AND ANTI CANCER ACTIVITY OF Ipomoea Sepiaria METHANOLIC EXTRACT AGAINST PC-3 CELL LINE”. Asian Journal of Advances in Medical Science 2 (1):88-94. https://journalmedicals.com/index.php/AJOAIMS/article/view/23.

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