Asian Journal of Advances in Medical Science

Chronic Kidney Disease (CKD) is characterized by progressive loss of kidney function, often leading to the need for renal replacement therapy, such as dialysis or transplantation. It is represented by the presence of kidney damage or an estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m², persisting for 3 months or more. The herbal plant Orthosiphon aristatus commonly known as Poonaimeesai belongs to the family Lamiaceae and has been documented as an anti-proliferative, antioxidant, analgesic, anti-inflammatory, antimicrobial, and diuretic properties. Preliminary molecular docking study through computational analysis was done with the Auto Dock tool (Version 1.5.7) to study the efficacy of the plant constituents against renal failure. The phytoconstituents present in Orthosiphon aristatus were identified and retrieved through literature survey. The potential action of Orthosiphon aristatus against various targets involved in renal function was compared with allopathic standard drug Pentoxifylline for its action of reducing proteinurea and maintaining eGFR. From the Study, phytoconstituents present in Orthosiphon aristatus shows effective binding action ranging from -3 to -9 against various targets (ATP- binding Cassette, P53, CYP1B1, ADORA1, ADORA2A) involved in pathogenesis of Chronic renal failure. The constituents present in the herb Orthosiphon aristatus (Sinensetin, Rosmarinic acid, Eupatorin, Ladanein and Salvigenin) has inherent action on renal function by binding with various targets has been concluded by the present study.