Adverse Effects of Radiation on Liver and Kidney Functions
Muna A. Hussein
Department of Biochemistry, Faculty of Medicine, University of Kerbala, Iraq.
Noor Flayyih Hasan *
Department of Microbiology, College of Medicine, University of Karbala, Karbala, Iraq.
*Author to whom correspondence should be addressed.
Abstract
This research aimed to investigate the biological impacts of radiograph on liver and kidney functions. Hilla city radiation-exposed medical personnel with modest doses were studied for hepatic and renal function in 2023-2024.Workers who had received modest doses of radiation were enrolled as participants after giving their informed agreement. The radiation-exposed personnel served an average of two consecutive two-year terms (2023–2024). Employees who had not been exposed to radiation as controls (n=20) were also included, and they had been matched for age and had the same socioeconomic status as the exposed workers. Individuals in the control group were likewise employed by the same institution. All of the individuals had their medical and background information gathered. Informed permission was obtained from radiation-exposed and non-radiation-exposed hospital staff to collect blood samples from the participants (n=100). Each participant filled out a proforma with their basic background information. In the biochemistry lab, ALT in U/L, AST in U/L, bilirubin mg/dl, urea, creatinine were measured for radiation-exposed (n=80) and radiation-unexposed personnel (n=20). These tests were done according to manufacturer instructions (Biolabo company). Workers who had been exposed to radiation had higher levels of ALT, AST, and bilirubin, with mean values of 46.1 U/L, 29.3, and 0.6, respectively, than those who had not been exposed. Radiation-exposed employees had higher levels of urea and creatinine than non-exposed individuals.
In conclusion, Radiation cause alteration in liver and kidney functions as a results of tissue injury.
Keywords: Kidney, liver, radiation, radiograph