Evaluation of Alternanthera sessilis Linn against Diabetes Induced Retinopathy in Rats

PDF Review History

Published: 2024-06-06

Page: 79-83


Panga Swarna

Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Autonomous, KR Palli cross, Chiyyedu (Post), Anantapur, Andhrapradesh – 515721, India.

Kanala Somasekhar Reddy

Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Autonomous, KR Palli cross, Chiyyedu (Post), Anantapur, Andhrapradesh – 515721, India.

Onchonga Ondabu Rogers *

Department of Pharmacy Practice, Raghavendra Institute of Pharmaceutical Education and Research (RIPER, Autonomous, KR Palli cross, Chiyyedu (Post), Anantapur, Andhrapradesh – 515721, India.

*Author to whom correspondence should be addressed.


Abstract

Diabetes Retinopathy (DR) is a major microvascular complication occurs due to the Chronic Diabetes.  The objective of present study is to evaluate the Alternanthera sessilis Linn against Diabetes Induced Retinopathy in Rats. Diabetes was induced in rats by injecting 120 mg/kg of Alloxan monohydrate intra-peritoneally to overnight-fasted rats (12 h). After 72 h of injection, fasting blood glucose level was measured. Diabetic animals were separated into six groups (n = 6). Group 1 (normal control), received vehicle orally. Group 2 (Diabetic control group), received 1 ml of normal saline. Group 3 (reference group): Diabetics rats, received  Glibenclamide (10 mg/kg b w, p. o).  Group 4 and 5 (Test group-1 and Test group-2 respectively), received the ethanolic extract of Alternanthera Sessilis 500 and 1000 mg/kg bw respectively and the treatment was continued for 42 days. At the end of the study blood was collected from retro orbital plexus for estimation of biochemical parameters and antioxidant parameters. Diabetic rats exhibited the significant increase in blood glucose, total cholesterol, triglycerides, lipid peroxidation, aldose reductase and significant decrease in superoxide dismutase, catalase, reduced glutathione in comparison to normal rats. Diabetic rats treated with ethanolic extract of Alternanthera Sessilis at doses of 500 and 1000 mg/kg b w showed significant decrease in blood glucose, total cholesterol, triglycerides, lipid peroxidation, aldose reductase and significant increase in superoxide dismutase, catalase, reduced glutathione in comparison to diabetic rats in dose dependent manner.

Keywords: Alternanthera Sessilis, diabetic retinopathy, diabetic parameters and oxidative parameters


How to Cite

Swarna, P., Reddy, K. S., & Rogers, O. O. (2024). Evaluation of Alternanthera sessilis Linn against Diabetes Induced Retinopathy in Rats. Asian Journal of Advances in Medical Science, 6(1), 79–83. Retrieved from https://journalmedicals.com/index.php/AJOAIMS/article/view/144


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