Exploring the Therapeutic Potential of Rosemary: An In-depth Review of its Pharmacological Properties

PDF Review History

Published: 2024-01-08

Page: 19-31


Y. Sai Charan Teja

Riper, K. R. Palli Cross, Anantapur, Under Jntua, India.

L. S. Jyothika

Riper, K. R. Palli Cross, Anantapur, Under Jntua, India.

N. Vasavi

Riper, K. R. Palli Cross, Anantapur, Under Jntua, India.

K. Soma Sekhar Reddy

Riper, K. R. Palli Cross, Anantapur, Under Jntua, India.

A. Sudheer *

Riper, K. R. Palli Cross, Anantapur, Under Jntua, India.

*Author to whom correspondence should be addressed.


Abstract

The pharmacological effects of rosemary plant period a wide range and include anti-inflammatory and antioxidant properties. Rosemary is shown to have its potential on Ischemic stroke because of its Anti-oxidant and Anti-inflammatory properties. It contains strong antioxidants such carnosol, which has anti-inflammatory properties, and Rosmarinus acid, which fights oxidative stress. Rosemary is an attractive possibility for treating disorders like oxidative-related diseases because of its dual activity. Additionally, Rosemary has shown neuroprotective qualities that aid in maintaining brain health and cognitive function. The aromatic components in its essential oil may improve concentration and memory. Rosemary has also been investigated for its potential in hair care, with research indicating that it can encourage hair growth. These rosemary Officinalis also have different chemical substances and compounds like Terpenes, Essential oils, Bicyclic monoterpenes, Monoterpenoids, Ester and also, we have different pharmacological activates they are Anti-oxidative, Anti-inflammatory, Anti-microbial, Anti-obesity, Anti-fungal, Anti-cancer, Anti-diabetic, Cardiovascular activity, Skin health, Neuroprotective, Gastrointestinal, Sperm motility, Anti-depressant, Anti-viral activity.

Keywords: Anti-microbial, anti-oxidant, biological activities, carnosic acid, phenolic acid, rosmaric acid, urosolic acid


How to Cite

Teja , Y. S. C., Jyothika , L. S., Vasavi , N., Reddy , K. S. S., & Sudheer , A. (2024). Exploring the Therapeutic Potential of Rosemary: An In-depth Review of its Pharmacological Properties. Asian Journal of Advances in Medical Science, 6(1), 19–31. Retrieved from https://journalmedicals.com/index.php/AJOAIMS/article/view/141


References

Alanazi AM. The cytotoxicity effect of rosemary and myrrh extracts on cancer cell lines: Tennessee State University; 2016.

Dafni A, Petanidou T, Vallianatou I, Kozhuharova E, Blanche C, Pacini E, et al. Myrtle, basil, Rosemary, and three-lobed sage as ritual plants in the monotheistic religions: An historical–ethnobotanical comparison. Economic Botany. 2020;74:330-55.

Stefanaki A, van Andel T. Mediterranean aromatic herbs and their culinary use. Aromatic Herbs in Food: Elsevier. 2021;93-121.

Trajkovska-Broach A, Petkoska AT. Nutritional Values and Therapeutical Effects of Mediterranean Herbs, Spices, and Medicinal Plants. Herbs and Spices-New Advances: IntechOpen; 2022.

Abbas WA, Tawfeeiq AM, editors. Effect of Different Levels of Pruning and Nitrogen Fertilizer on the Quality and Quantity of the Volatile Oil of Rosmarinus officinalis L. IOP Conference Series: Earth and Environmental Science: IOP Publishing; 2023.

Lam M, Khoshkhat P, Chamani M, Shahsavari S, Dorkoosh FA, Rajabi A, et al. In-depth multidisciplinary review of the usage, manufacturing, regulations & market of dietary supplements. Journal of Drug Delivery Science and Technology. 2022;67:102985.

Daneshniya M, Maleki MH, Daneshniya MR. The Antioxidant and Antimicrobial Potential of Persian Indigenous Herbs as an Alternatives for Nitrate and Nitrite in the Preservation of Meat and Meat Products: An Overview. European Journal of Nutrition & Food Safety. 2023;15(9):73-105.

Asgari M, Kazemi M, Sourastani MM, Sharififard M. Chemical analysis of Eucalyptus and Rosemary essential oils using gas chromatography-mass spectrometry (GC-MS) and evaluation of their toxicity against the most common urban pest. Analytical Methods in Environmental Chemistry Journal. 2023; 6(03):89-102.

Alsamri H, Al Dhaheri Y, Iratni R. Targeting Triple-Negative Breast Cancer by the Phytopolyphenol Carnosol: ROS-Dependent Mechanisms. Antioxidants. 2023;12(7):1349.

Kishi C, Higashihara M, Takemoto Y, Kamei M, Yoshioka Y, Matsumura S, et al. Inhaled volatile β-caryophyllene is incorporated into the aortic wall and attenuates nicotine-induced aorta degeneration via a CB2 receptor-dependent pathway. Biomedicine & Pharmacotherapy. 2022;153:113423.

Rosero S, Del Pozo F, Simbaña W, Álvarez M, Quinteros MF, Carrillo W, Morales D. Polyphenols and flavonoids composition, anti-inflammatory and antioxidant properties of Andean Baccharis macrantha extracts. Plants. 2022;11(12):1555.

Rakha A, Umar N, Rabail R, Butt MS, Kieliszek M, Hassoun A, Aadil RM. Anti-inflammatory and anti-allergic potential of dietary flavonoids: A review. Biomedicine & Pharmacotherapy. 2022;156:113945.

Alhasso B, Ghori MU, Conway BR. Systematic review on the effectiveness of essential and carrier oils as skin penetration enhancers in pharmaceutical formulations. Scientia Pharmaceutica. 2022;90(1):14.

Karaca Öner E, Yeşil M, Odabas MS. Prediction of secondary metabolites content of laurel (Laurus nobilis L.) with Artificial Neural Networks Based on Different Temperatures and Storage times. Journal of Chemistry. 2023;2023.

De Falco E, Rigano D, Fico V, Vitti A, Barile G, Pergola M. Spontaneous officinal plants in the Cilento, Vallo di Diano and Alburni National Park: Tradition, protection, enhancement, and recovery. Plants. 2023; 12(3):465.

Mehta S, MacGillivray M. Aromatherapy in textiles: A systematic review of studies examining textiles as a potential carrier for the therapeutic effects of essential oils. Textiles. 2022;2(1):29-49.

Nollet LM. Terpenes and Terpenoids Containing Food Spices. Analysis of Food Spices: CRC Press. 2023;19-28.

Celik H, İlhan K. Antioxidant effective aromatic compounds. Life in extreme environments-diversity, Adaptability and Valuable Resources of Bioactive Molecules; 2023.

Shirdhone MBS, Patil MAS, Chougule N, MS M, Bhadalekar M, Bhosale M. Anticancer and Other Therapeutic Effects of Rosemary.

Jordamović N, Pehlivanović B, Nikšić H, Gušić I, Korić E, Dedić M, et al. Anti-proliferative and anti-inflammatory activity of triterpene extracts from plant species belonging to Lamiaceae family. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas. 2023; 22(6).

Grigore A, Vulturescu V, Neagu G, Ungureanu P, Panteli M, Rasit I. Antioxidant–Anti-Inflammatory Evaluation of a Polyherbal Formula. Pharmaceuticals. 2022;15(2):114.

Josimuddin S, Kumar M, Rastogi H. A review on nutritional and medicinal value of malus domestica with various activity. Int J Health Sci. 2022;6:7251-65.

Sidiropoulou E, Marugán-Hernández V, Skoufos I, Giannenas I, Bonos E, Aguiar-Martins K, et al. In vitro antioxidant, antimicrobial, anticoccidial, and anti-inflammatory study of essential oils of oregano, thyme, and sage from Epirus, Greece. Life. 2022;12(11):1783.

Mirza FJ, Zahid S, Holsinger RD. Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action. Molecules. 2023;28(5):2306.

de Macedo LM, Santos ÉMd, Militão L, Tundisi LL, Ataide JA, Souto EB, Mazzola PG. Rosemary (Rosmarinus officinalis L., syn Salvia rosmarinus Spenn.) and its topical applications: A review. Plants. 2020;9(5):651.

Namdeo P, Gidwani B, Tiwari S, Jain V, Joshi V, Shukla SS, et al. Therapeutic potential and novel formulations of ursolic acid and its derivatives: An updated review. Journal of the Science of Food and Agriculture; 2023.

Chou S-T, Lin T-H, Peng H-Y, Chao W-W. Phytochemical profile of hot water extract of Glechoma hederacea and its antioxidant, and anti-inflammatory activities. Life sciences. 2019;231:116519.

Sarankar SK, Rajak B, Ojha S, Somkuwar S. Exploring the utilization of phenolic compounds in pharmaceuticals and healthcare. GSC Biological and Pharmaceutical Sciences. 2023;24(3):095-102.

Kompelly A, Kompelly S, Vasudha B, Narender B. Rosmarinus officinalis L.: An update review of its phytochemistry and biological activity. Journal of Drug Delivery and Therapeutics. 2019;9(1):323-30.

Egbuta MA, McIntosh S, Waters DL, Vancov T, Liu L. In Vitro Anti-Inflammatory Activity of Essential Oil and β-Bisabolol Derived from Cotton Gin Trash. Molecules. 2022;27(2):526.

Günther M, Karygianni L, Argyropoulou A, Anderson AC, Hellwig E, Skaltsounis AL, et al. The antimicrobial effect of Rosmarinus officinalis extracts on oral initial adhesion ex vivo. Clinical Oral Investigations. 2022;26(6):4369-80.

Mohammadi S, Moosaie F, Aarabi MH. Understanding the immunologic characteristics of neurologic manifestations of SARS-CoV-2 and potential immunological mechanisms. Molecular neurobiology. 2020;57:5263-75.

Satoh T, Trudler D, Oh C-K, Lipton SA. Potential therapeutic use of the rosemary diterpene carnosic acid for Alzheimer’s disease, Parkinson’s disease, and long-COVID through NRF2 activation to counteract the NLRP3 inflammasome. Antioxidants. 2022;11(1):124.

Hussain MA, Sumon TA, Mazumder SK, Ali MM, Jang WJ, Abualreesh MH, et al. Essential oils and chitosan as alternatives to chemical preservatives for fish and fisheries products: A review. Food Control. 2021;129:108244.

Pérez-Sánchez A, Barrajón-Catalán E, Ruiz-Torres V, Agulló-Chazarra L, Herranz-López M, Valdés A, et al. Rosemary (Rosmarinus officinalis) extract causes ROS-induced necrotic cell death and inhibits tumor growth in vivo. Scientific Reports. 2019;9(1):808.

Veenstra JP, Johnson JJ. Rosemary (Salvia rosmarinus): Health-promoting benefits and food preservative properties. International Journal of Nutrition. 2021; 6(4):1.

Gao X, Liu J, Li L, Liu W, Sun M. A brief review of nutraceutical ingredients in gastrointestinal disorders: Evidence and suggestions. International Journal of Molecular Sciences. 2020;21(5):1822.

Arora R, Aggarwal G, Dhingra GA, Nagpal M. Herbal active ingredients used in skin cosmetics. Asian J Pharm Clin Res. 2019;12(9):7-15.

Sahiner M, Yilmaz AS, Gungor B, Ayoubi Y, Sahiner N. Therapeutic and nutraceutical effects of polyphenolics from natural sources. Molecules. 2022;27(19):6225.

Patrignani F, Prasad S, Novakovic M, Marin PD, Bukvicki D. Lamiaceae in the treatment of cardiovascular diseases. Frontiers in Bioscience. 2021;26(4):612-43.

Yánez-Ortiz I, Catalán J, Rodríguez-Gil JE, Miró J, Yeste M. Advances in sperm cryopreservation in farm animals: Cattle, horse, pig and sheep. Animal Reproduction Science. 2022;246:106904.

Hasanpour M, Iranshahy M, Iranshahi M. The application of metabolomics in investigating anti-diabetic activity of medicinal plants. Biomedicine & Pharmacotherapy. 2020;128:110263.

Al Zarzour RH, Kamarulzaman EE, Saqallah FG, Zakaria F, Asif M, Razak KNA. Medicinal plants’ proposed nanocomposites for the management of endocrine disorders. Heliyon; 2022.

Zhang J, Zhang M, Bhandari B, Wang M. Basic sensory properties of essential oils from aromatic plants and their applications: A critical review. Critical Reviews in Food Science and Nutrition. 2023:1-14.

Maratha S, Sharma V, Walia V. Alternative Therapeutic Strategies for the Treatment of Depressive Disorders-A Review. Annals of the Romanian Society for Cell Biology. 2022;26(01):903–16-–16.

Steenkamp V, Parkar H, Dasgupta A. Utility of Therapeutic Drug Monitoring in Identifying Clinically Significant Interactions Between St. John's Wort and Prescription Drugs. Therapeutic Drug Monitoring. 2023;45(1):35-44.

Hansbro P. The Good Gut Anti-Inflammatory Diet: Beat whole body inflammation and live longer, happier, healthier and younger: Pantera Press; 2023.

Shimira F, Zahid G, Nyirahabimana F. An Overview and Renewed Emphasis on Ethnopharmacology of Rosemary (Salvia Rosmarinus). Current Perspectives on Medicinal and Aromatic Plants (CUPMAP). 2022;5(1):30-41.

Brewer-Smyth K. Brain Food: The Impact of Diet, Nutrition, and Nutraceuticals on the Brain and the Microbiota-Gut-Brain Axis. Adverse Childhood Experiences: The Neuroscience of Trauma, Resilience and Healing throughout the Life Course: Springer. 2022;303-57.

Patel U, Desai K, Dabhi RC, Maru JJ, Shrivastav PS. Bioprospecting phytochemicals of Rosmarinus officinalis L. for targeting SARS-CoV-2 main protease (Mpro): a computational study. Journal of Molecular Modeling. 2023;29(5):161.

Bekut M, Brkić S, Kladar N, Dragović G, Gavarić N, Božin B. Potential of selected Lamiaceae plants in anti (retro) viral therapy. Pharmacological research. 2018;133:301-14.

Behl T, Rocchetti G, Chadha S, Zengin G, Bungau S, Kumar A, et al. Phytochemicals from plant foods as potential source of antiviral agents: An overview. Pharmaceuticals. 2021;14(4):381.

El Menyiy N, Aboulaghras S, Bakrim S, Moubachir R, Taha D, Khalid A, et al. Genkwanin: An emerging natural compound with multifaceted pharmacological effects. Biomedicine & Pharmacotherapy. 2023;165:115159.

Romanescu M, Oprean C, Lombrea A, Badescu B, Teodor A, Constantin GD, et al. Current State of Knowledge Regarding WHO High Priority Pathogens—Resistance Mechanisms and Proposed Solutions through Candidates such as Essential Oils: A Systematic Review. International Journal of Molecular Sciences. 2023;24(11):9727.

Bencharif-Betina S, Benhamed N, Benabdallah A, Bendif H, Benslama A, Negro C, et al. A Multi-Approach Study of Phytochemicals and Their Effects on Oxidative Stress and Enzymatic Activity of Essential Oil and Crude Extracts of Rosmarinus officinalis. Separations. 2023; 10(7):394.

Valková V, Ďúranová H, Galovičová L, Vukovic NL, Vukic M, Kačániová M. In Vitro antimicrobial activity of lavender, mint, and rosemary essential oils and the effect of their vapours on growth of Penicillium spp. in a bread model system. Molecules. 2021;26(13):3859.

Ben Arfa A, Gouja H, Hannachi H, Isoda H, Neffati M, Najjaa H. Seasonal changes in rosemary species: A chemotaxonomic assessment of two varieties based on essential oil compounds, antioxidant and antibacterial activities. Plos One. 2022; 17(8):e0273367.

Balasubramaniyam T, Choi S-R, Nathan VK, Basu A, Lee J-H. A New Perspective on Metabolites and Bioactive Compounds from Fungi. The American Journal of Chinese Medicine. 2023;1-27.

Guimarães NS, Ramos VS, Prado-Souza LF, Lopes RM, Arini GS, Feitosa LG, et al. Rosemary (Rosmarinus officinalis L.) Glycolic Extract Protects Liver Mitochondria from Oxidative Damage and Prevents Acetaminophen-Induced Hepatotoxicity. Antioxidants. 2023;12(3): 628.